Clindamycin Phosphate Used in Combination with Tretinoin in the Treatment of Acne

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Abstract
Sixty-four patients with acne were studied to evaluate the irritancy, tolerance, and systemic absorption of topical 1% clindamycin phosphate when combined with tretinoin gel 0.025% as compared to either agent alone. All these treatment regimens were effective and well-tolerated. Clindamycin alone was less irritating than tretinoin alone or tretinoin combined with clindamycin. The combination treatment produced fewer complaints from patients than tretinoin alone. No systemic absorption of clindamycin was detected after two weeks and eight weeks of usage.

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