EFFECTS OF LIPID-PEROXIDATION ON PROSTAGLANDIN SYNTHESIS IN RABBIT KIDNEY MEDULLA SLICES

  • 1 January 1982
    • journal article
    • research article
    • Vol. 710  (1) , 82-86
Abstract
Ascorbic acid and Fe2+ had a more powerful stimulatory effect on the lipid peroxidation of rabbit kidney medullar slices in 0.15 M KCl/0.02 M Tris-HCl buffer than in Krebs-Henseleit buffer. The lipid peroxidation induced by ascorbic acid and Fe2+ enhanced the release of unsaturated fatty acids from tissue lipids, but inhibited medullary generation of prostaglandin [PG] E. The lipid peroxidation induced by ascorbic acid and Fe2+ may inhibit the formation of PGE; this inhibitory effect may be mediated by lipid peroxides via the inhibition of PG synthetase.

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