Inhibition of oxidative enzymes by anti-allergy drugs
- 1 November 1981
- journal article
- research article
- Published by Springer Nature in Inflammation Research
- Vol. 11 (5) , 503-509
- https://doi.org/10.1007/bf02004713
Abstract
Lodoxamide tromethamine and several other antiallergy drugs, i.e. inhibitors of rat passive cutaneous anaphylaxis, are inhibitors of purified xanthine oxidase. Inhibition is noncompetitive withK i's in the 1–13 micromolar range. Lodoxamide tromethamine had no effect on another flavoprotein, glucose oxidase. Other studies have shown several of these drugs are inhibitors of aldose reductase. It is speculated that the anti-allergy drugs inhibit mediator release from mast cells by blocking univalent electron transfers which are essential for release.This publication has 32 references indexed in Scilit:
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