INFLUENCE OF ESTRADIOL AND TESTOSTERONE PROPIONATES ON SKELETAL ATROPHY FROM DISUSE AND ON NORMAL BONES OF MATURE RATS11

Publisher Website
Google Scholar
Abstract
Using mature [male] rats, the effects of orchidectomy and of the adm. of testosterone and estradiol propionates on the humeri of normally innervated limbs and on the atrophy occurring in the humeri of paralyzed limbs have been investigated. Orchidectomy decreased the % of ash of both humeri as did also the daily adm. of large doses of testosterone propionate. The % of ash of both humeri were increased above their probable original ash content by the subcut. injn. of 10 and of 5 [gamma] of estradiol di-propionate on alternate days. This result was not obtained in animals receiving 50 [gamma] of the same substance. Orchidectomy increased the degree of bony atrophy, an effect which was prevented by the adm. of large doses of test-osterone propionate. Treatment of the animals with estra-diol dipropionate reduced the bony atrophy and the greatest effect was obtained with doses of 5 7 of the estrogen ad- ministered on alternate days, in which case the atrophy was prevented.