EFFICACY OF IVERMECTIN (22,23-DIHYDROAVERMECTIN-B1) AGAINST GASTROINTESTINAL PARASITES IN PONIES

  • 1 January 1980
    • journal article
    • research article
    • Vol. 41  (11) , 1747-1750
Abstract
The controlled test method was used to evaluate the antiparasitic efficacy of i.m. inoculated 22,23-dihydroavermectin B1 (ivermectin) against gastrointestinal parasites of horses (ponies). Parasite infections were naturally acquired in southern Louisiana [USA]. Dose levels of the drug tested were 0.2, 0.3 and 0.5 mg/kg. Ivermectin at all dose levels tested had an efficacy greater than 97% (P < 0.05) against Gasterophilus intestinalis larvae, Trichostrongylus axei, Oxyuris equi larvae, Strongylus vulgaris, S. edentatus, 15 spp. of small strongyles and small strongyle larvae. Ponies were less uniformly infected with Habronema sp. larvae, G. nasalis larvae, Parascaris equorum, O. equi adults, Anoplocephala perfoliata, S. equinus and 11 small strongyle species, and statistical analysis was not possible to do. Observations indicate that the drug was also highly effective against these species. There were no gross or clinical reactions observed in treated animals. Dissections of the injection sites revealed spindle-shaped lesions, 3-5 cm long, in a few ponies in all treatment groups, including those given the placebo injection.

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