THE ACTION OF HEPARIN, SERUM ALBUMIN (CRYSTALLINE), AND SALMINE ON BLOOD-CLOTTING MECHANISMS (IN VITRO)

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Abstract
An exptl. analysis was made of the effects of serum albumin, salmine, and heparin on the isolated 1st and 2d phases of blood-clotting reactions. Acid-base influences were investigated. Crystalline serum albumin has a nonspecific thromboplastic action in the prothrombin [forward arrow] thrombin phase and a slight effect (usually antithrombic) in the thrombin + fibrinogen interaction. These phenomena are unimportant in relation to natural coagulation mechanisms. The purified albumin unlike crude plasma "albumin" preps., does not produce a marked synergistic antithrombic action, in conjunction with heparin. Salmine is antipro-thrombic in the 1st phase and fibrinoplastic in the 2d. The inhibition preponderates in plasma. Both actions are antagonized by heparin. Heparin is antiprothrombic in the 1st phase, to a degree and duration depending on quantitative relations to the thromboplastic factors. In the 2d phase, it has a minor immediate (nonprogressive) antithrombic effect, exaggerated (usually) by albumin and antagonized by salmine. The significant anticoagulant effects in these studies are the antiprothrombic actions of heparin and salmine.

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