Axonal swellings in the corticospinal tracts in amyotrophic lateral sclerosis
- 1 June 1990
- journal article
- case report
- Published by Springer Nature in Acta Neuropathologica
- Vol. 80 (2) , 222-226
- https://doi.org/10.1007/bf00308929
Abstract
Summary In 2 of 16 cases with sporadic amyotrophic lateral sclerosis (ALS) large numbers of axonal swellings were observed in the corticospinal tracts over a region extending from the posterior limbs of internal capsules to the bulbar pyramids. On electron microscopy, these axonal swellings were seen to consist of accumulations of neurofilaments and altered neuronal organelles (mitochondria and secondary lysosomes). Their morphology differed from the spheroids seen in the anterior horn in ALS.Keywords
This publication has 14 references indexed in Scilit:
- Amyotrophic leteral sclerosis: Part 2. EtiopathogenesisAnnals of Neurology, 1985
- Amyotrophic lateral sclerosis: Part 1. Clinical features, pathology, and ethical issues in managementAnnals of Neurology, 1985
- Fine Structural Observations of Neurofilamentous Changes in Amyotrophic Lateral SclerosisJournal of Neuropathology and Experimental Neurology, 1984
- NODES OF RANVIER IN PATHOLOGICAL CONDITIONSPublished by Elsevier ,1984
- THE EARLY EVOLUTION OF NEUROFILAMENTOUS ACCUMULATIONS DUE TO 2,5‐HEXANEDIOL IN THE OPTIC PATHWAYS OF THE RATNeuropathology and Applied Neurobiology, 1982
- Does a defect of energy metabolism in the nerve fiber underlie axonal degeneration in polyneuropathies?Annals of Neurology, 1979
- The central nervous system in motor neurone diseaseJournal of Neurology, Neurosurgery & Psychiatry, 1970
- Proximal axonal enlargement in motor neuron diseaseNeurology, 1968
- NERVE FIBRE DEGENERATION IN THE BRAIN IN AMYOTROPHIC LATERAL SCLEROSISJournal of Neurology, Neurosurgery & Psychiatry, 1960
- AMYOTROPHIC LATERAL SCLEROSISA.M.A. Archives of Neurology & Psychiatry, 1953