MODIFICATION OF CELL MEMBRANE COMPOSITION BY DIETARY LIPIDS AND ITS IMPLICATIONS FOR ATHEROSCLEROSIS
- 16 December 1983
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 414 (1) , 29-43
- https://doi.org/10.1111/j.1749-6632.1983.tb31672.x
Abstract
Dietary lipids can modify the properties of cell membranes, including membrane fluidity and membrane permeability. The saturation and isomerization of dietary fatty acids may affect the pattern of fatty acids acylated to glycerol in phospholipids. Oxidized sterols may affect membrane properties directly by their insertion in the membrane or indirectly through their effects on lipid metabolism. The flow of calcium and other nutrients into the cells appears to be a major property affected by those changes in lipid composition of membranes and may be important in the onset of atherosclerosis. The factors that alter the character of the lipids in cell membranes should receive increased study in both in vitro and in vivo systems to clarify their role in diseases processes.Keywords
This publication has 72 references indexed in Scilit:
- THE EFFECT OF MEMBRANE LIPID COMPOSITION ON THE PERMEABILITY OF MEMBRANES TO Ca2+*Annals of the New York Academy of Sciences, 1983
- Effect of Ca2+ blocking agents on the metabolism of low density lipoproteins in human skin fibroblastsBiochemical and Biophysical Research Communications, 1982
- Atherosclerosis: Prevention by Agents Not Affecting Abnormal Levels of Blood LipidsScience, 1981
- A specific, high affinity binding protein for 1α,25-dihydroxy vitamin D in the chick oviduct shell glandBiochemical and Biophysical Research Communications, 1980
- Studies on the mode of action of calciferol XVIII. Evidence for a specific high affinity binding protein for 1,25 dihydroxyvitamin D3 in chick kidney and pancreasBiochemical and Biophysical Research Communications, 1979
- Regulation of membrane enzymes by lipidsBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1978
- The function of sterols in membranesBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1976
- Major lipid classes in plasma membrane isolated from liver of rats fed a hepatocarcinogenBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1976
- Cholesterol, 7-ketocholesterol and 25-hydroxycholesterol uptake studies and effect on 3-hydroxy-3-methylglutaryl-coenzyme a reductase activity in human fibroblastsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975
- Cholesterol and cell membrane function: A hypothesis concerning the etiology of atherosclerosisJournal of Theoretical Biology, 1974