The superfamily of heptahelical receptors
Top Cited Papers
- 1 July 2000
- journal article
- review article
- Published by Springer Nature in Nature Cell Biology
- Vol. 2 (7) , E133-E136
- https://doi.org/10.1038/35017152
Abstract
Despite a growing appreciation of functional analogies between visual and hormonal signalling systems in the early 1980s, the discovery of the close structural relationship between rhodopsin and the β2-adrenergic receptor, and of the existence of a larger ‘superfamily’ of such receptors, came as a total surprise. Here I provide a personal perspective on events leading up to and flowing from this exciting discovery that opened up a vast field of research.Keywords
This publication has 57 references indexed in Scilit:
- Cell Surface Receptors: A Short Course on Theory and MethodsPublished by Springer Nature ,1996
- G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALSAnnual Review of Biochemistry, 1987
- Pertussis toxin substrate, the putative Ni component of adenylyl cyclases, is an alpha beta heterodimer regulated by guanine nucleotide and magnesium.Proceedings of the National Academy of Sciences, 1983
- Purification of the regulatory component of adenylate cyclase.Proceedings of the National Academy of Sciences, 1980
- Catecholamine-stimulated GTPase activity in turkey erythrocyte membranesBiochimica et Biophysica Acta (BBA) - Enzymology, 1976
- The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat LiverPublished by Elsevier ,1971
- Adenyl Cyclase in Fat CellsPublished by Elsevier ,1969
- ADENYL CYCLASE AS AN ADRENERGIC RECEPTOR*Annals of the New York Academy of Sciences, 1967
- Distinct Subunits for the Regulation and Catalytic Activity of Aspartate Transcarbamylase*Biochemistry, 1965
- On the contraction of muscle, chiefly in relation to the presence of ‘receptive’ substancesThe Journal of Physiology, 1909