Pulmonary infection with capsule-deficientCryptococcus neoformans

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Abstract
A case of bilateral lobar pneumonia due toCryptococcus neoformans is presented. The capsule-deficient fungal organisms within tissue were suggestive ofHistoplasma capsulatum. Cultures grewCryptococcus neoformans and there was cryptococcal antigen in the serum. Pulmonary cryptococcosis and the occurrence of unencapsulated cryptococci are reviewed. The important role both culture and the latex agglutination test for cryptococcal antigen play in the differential diagnosis of systemic fungal infections with over-lapping histopathology are discussed.