Experimental feline Toxoplasmosis.

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Abstract
The route of inoculation as well as stage of inoculated organism in its life cycle influenced the pathogenicity or infectivity of Toxoplasma in cats. All 6 cats administered orally with Toxoplasma cysts were infected without any clinical symptoms and excreted oocysts in the feces at the early stage of infection (5-12 days after administration). Of 3 cats administered orally with Toxoplasma oocysts, only 1 animal developed latent infection excreting oocysts in the feces at the end of the 5th wk after administration (38th, 40th day). On postmortem examination, infected animals showed no abnormalities. Toxoplasma was recovered from the the lung, striated muscle and other tissues. When cats were inoculated with cysts, all developed fatal infections. Clinical signs were fever, anorexia, lethargy and dyspnea, similar to those of cats infected naturally. Postmortem examination showed that a large amount of fluid accumulated in the pleural and peritoneal cavities. Cloudy swelling of the liver and edema of the lung were observed. The level of SGOT [serum glutamic oxaloacetic transaminase] and SGPT [serum glutamic pyruvic transaminase] values was elevated significantly. No animals inoculated i.p. with cysts excreted oocysts in their feces, although Toxoplasma was recovered from all tissues and organs. I.m. inoculation of cortisone acetate did not affect relapsing or oocyst production.

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