Requirement for Tumor Necrosis Factor Receptor 2 Expression on Vascular Cells To Induce Experimental Cerebral Malaria
Open Access
- 1 October 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (10) , 5857-5859
- https://doi.org/10.1128/iai.70.10.5857-5859.2002
Abstract
Using tumor necrosis factor receptor type 2 (TNFR2)-deficient mice and generating bone marrow chimeras which express TNFR2 on either hematopoietic or nonhematopoietic cells, we demonstrated the requirement for TNFR2 expression on tissue cells to induce lethal cerebral malaria. Thus, TNFR2 on the brain vasculature mediates tumor necrosis factor-induced neurovascular lesions in experimental cerebral malaria.Keywords
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