Quinidine Effects Due to Disopyramide

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To the Editor: The following report demonstrates electrocardiographic abnormalities secondary to disopyramide that resemble quinidine effects: prolongation of QRS complex, lengthening of Q-T interval and prominent U waves. Ventricular fibrillation developed shortly after disopyramide therapy was begun, suggesting that this arrhythmia resulted from disopyramide, a side effect similar to that reported from quinidine and termed "quinidine syncope."1 An 81-year-old woman entered New Rochelle Hospital with increasing dyspnea. She had been hospitalized two years earlier with congestive heart failure. At that time, monitoring revealed frequent bursts of ventricular tachycardia lasting 3 to 5 beats. Therapy with procainamide, 500 mg every four . . .

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