Differential feedback regulation of the MAPK cascade underlies the quantitative differences in EGF and NGF signalling in PC12 cells
Open Access
- 5 October 2000
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 482 (3) , 169-174
- https://doi.org/10.1016/s0014-5793(00)02037-8
Abstract
Although epidermal growth factor (EGF) induces transient activation of Ras and the mitogen‐activated protein kinase (MAPK) cascade in PC12 cells, whereas nerve growth factor (NGF) stimulates sustaine...Keywords
This publication has 36 references indexed in Scilit:
- Emergent Properties of Networks of Biological Signaling PathwaysScience, 1999
- Analysis of Receptor Internalization as a Mechanism for Modulating Signal TransductionJournal of Theoretical Biology, 1998
- Signal transduction: Specificity of growth factors explained by parallel distributed processingMedical Hypotheses, 1996
- Activation of Epidermal Growth Factor Receptor by Epidermal Growth FactorBiochemistry, 1996
- Shc Isoform-specific Tyrosine Phosphorylation by the Insulin and Epidermal Growth Factor ReceptorsPublished by Elsevier ,1995
- Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell linesCurrent Biology, 1995
- EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptorCurrent Biology, 1994
- The GRB2/Sem‐5 adaptor proteinFEBS Letters, 1994
- A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transductionCell, 1992
- Signal transmission by epidermal growth factor receptor: coincidence of activation and dimerizationBiochemistry, 1992