Influence of the Liver on Uptake of Glucose by Extrahepatic Tissues

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Abstract
The maximal glucose utilization exhibited by the peripheral tissues (hind legs) of the eviscerated dog is approximately 600 mg/kg/hour, in con-trast with 1500 mg/kg/hour in the intact animal. This difference is independent of insulin, since the presence of supramaximal amounts of insulin cannot restore this utilization defect to the eviscerate animal, and high blood glucose levels alone can promote high uptake of sugar in the insulin-free depancreatized animal. The high glucose uptake of the peripheral tissues appears to be dependent upon the re-lease of some "humoral" influence by the liver in the presence of a carbohydrate load and can be demonstrated by cross-transfusion. The liver would appear therefore, to promote the peripheral storage and transformation of excess carbohydrate rather than serve itself as a major depot.

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