Renal tubular transport of proline, hydroxyproline, and glycine. II. Hydroxy-l-proline as substrate and as inhibitor in vivo.

Open Access
Publisher Website
Google Scholar
Abstract
Four healthy human adult males were infused with hydroxyl-L-proline and net renal tabular absorption of amino acid measured using conventional techniques and elution chromatography on ion exchange resin. A maximal rate for tubular absorption (Tin) of free hydroxy-L-prolene was observed (60-125 micro moles/min.) indicating a saturable transport mechanism for the imino acid. Hydroxy-L-proline is a specific inhibitor of tubular transport of L-proline and glycine, being more effective against the latter. Both imino acids have preference over glycine for transport by the group-specific system.