Cell-mediated immunity in experimental Nocardia asteroides infection

1 February 1977

journal article
research article
Published by American Society for Microbiology in Infection and Immunity

Vol. 15 (2) , 370-375
https://doi.org/10.1128/iai.15.2.370-375.1977

Abstract

Experimental mycetoma-like lesions developed in guinea pigs after s.c. injection of N. asteroides. Although delayed hypersensitivity appeared earlier, increased macrophage migration inhibition and microbicidal activity appeared after 7 wk. When the lesions healed, high cell-mediated immunity was present. Cell-mediated immunity was transferred to normal recipient guinea pigs from healed donor guinea pigs by spleen cell transfer. Recipient guinea pigs showed marked protection against challenge with N. asteroides.

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