REGULATION OF IMMUNE SYSTEM BY SYNTHETIC POLYNUCLEOTIDES .6. AMPLIFICATION OF IMMUNE-RESPONSE IN YOUNG AND AGING MICE

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 117  (2) , 423-427
Abstract
Model systems for study of the action of adjuvants in immunodeficient states were developed in 10 to 14 day old BALB/aj mice and aging BALB/aj mice (12-16 mo.). With sheep red blood cells as antigen, poly A:U was stimulatory in the neonatal and aging mice. The effect of poly A:U was similar to that seen when 5 .times. 106 thymocytes from immunologically mature mice were given with antigen. Cell-free supernatant fluids induced by incubation of poly A:U with thymocytes likewise were capable of restoring the number of antibody-forming cells to normalcy in aging mice.