Successful Subcutaneous Growth and Transplantation of Human Tumors in X-Irradiated Laboratory Animals.

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Abstract
100 human neoplasms were implanted subcutaneously in previously X-irradiated rats and mice as sieved or minced suspensions. At the end of 8 days in the heterologous hosts, 33 of the tumors showed no mitotic cells at the site of implantation though identifiable cancer cells might be present; these implantations were considered to be failures. 34 of the tumors showed cellular proliferation but could not be transferred successfully to a second heterologous host,while 33 tumors were transplanted for 2 generations or more with evidence of active growth and vascularization. Epidermoid carcinomas were most successfully propagated. Failures were in part due to infection and to delay between surgical removal of the tumor and its implantationin the heterologous hosts.

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