Antimicrobial Activity of Subinhibitory Concentrations of Aminoglycosides against Pseudomonas aeruginosa as Determined by the Killing-Curve Method and the Postantibiotic Effect
- 1 January 1991
- journal article
- research article
- Published by S. Karger AG in Chemotherapy
- Vol. 37 (2) , 114-121
- https://doi.org/10.1159/000238842
Abstract
This investigation used the postantibiotic effect (PAE) and killing curves to provide data on the antimicrobial activity of subinhibitory (1/8×, 1/4× and 1/2× minimum inhibitory concentration; MIC) and inhibitory (1 × MIC) concentrations of amikacin, gentamicin and tobramycin against Pseudomonas aeruginosa. Subinhibitory concentrations (l/4× and 1/2× MIC) of aminoglycosides demonstrated a reproducible PAE. At 1/4 × MIC, the order of duration of the PAE was approximately 15 min for all aminoglycosides, while at 1/2 × MIC all three aminoglycosides displayed a similar PAE of approximately 40 min. Killing-curve studies demonstrated that subinhibitory concentrations of aminoglycosides either decrease bacterial growth for several hours (1/4× and 1/2 × MIC) or produce stasis of growth for several hours (1/8 × MIC). Only inhibitory aminoglycoside concentrations (1 × MIC) proved to be bactericidal. Subinhibitory concentrations of aminoglycosides decrease bacterial growth and produce a PAE against P. aeruginosa.Keywords
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