Stop Flow Analysis of Renal Function in Newborn and Maturing Swine

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Abstract
The transfer of Na+, K+, Cl-, para-amino-hippurate, creatinine and inulin was studied in anesthetized swine with urine flow rates greater than 1 ml/kg min. Localization of transfer in the immature kidney did not differ from that of the 2-3 month old, morphologically mature kidney. The stop flow information from pigs up to 3 months old (older animals were not studied) was the same as that from adult dogs or sheep with these exceptions: the distal tubule did not secrete K+ readily and Na+ and Cl- were reabsorbed over a broad medial segment of the tubule.