Curve-fitting analysis of pressure-volume characteristics of the lungs
- 1 January 1977
- journal article
- research article
- Published by American Physiological Society in Journal of Applied Physiology
- Vol. 42 (1) , 111-116
- https://doi.org/10.1152/jappl.1977.42.1.111
Abstract
The pressure-volume relationship of the mammalian lung is markedly curvilinear and in the normal lung, can be shown to fit an exponential function of the form V = V0(1 - K 0e-K1P) in the range of lung volume from FRC to TLC. A method is presented, using a programmable calculator, of determining the parameters V0, K0, and K1, and of deriving related constants of greater physiological significance. Values calculated from pressure-volume curves of 20 normal human subjects are listed, together with coefficients of determination, to demonstrate the adequacy of fit of the method. Half-inflation pressure (h- ln 2/K1), ranged from 2.65 to 9.21 and coefficients of determination (r2) ranged from 0.851 to 0.9998.This publication has 3 references indexed in Scilit:
- High resolution display for variables in volume-displacement body plethysmography.Journal of Applied Physiology, 1966
- Improved technique for estimating pleural pressure from esophageal balloonsJournal of Applied Physiology, 1964
- An analysis of pressure-volume characteristics of the lungsJournal of Applied Physiology, 1964