Investigation of Ligand‐Receptor Systems by High‐Resolution Solid‐State NMR: Recent Progress and Perspectives
- 17 June 2005
- journal article
- review article
- Published by Wiley in Archiv der Pharmazie
- Vol. 338 (5-6) , 217-228
- https://doi.org/10.1002/ardp.200400991
Abstract
Solid‐state Nuclear Magnetic Resonance (NMR) provides a general method to study molecular structure and dynamics in a non‐crystalline and insoluble environment. We discuss the latest methodolo gical progress to construct 3D molecular structures from solid‐state NMR data obtained under magic‐angle‐spinning conditions. As shown for the neurotensin/NTS‐1 system, these methods can be readily applied to the investigation of ligand‐binding to G‐protein coupled receptors.Keywords
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