Catalytic Enantioselective Retro-Aldol Reactions: Kinetic Resolution ofβ-Hydroxyketones with Aldolase Antibodies

Publisher Website
Google Scholar
Abstract
High enantiomeric enrichment after 50% conversion: Racemates of aldols can be resolved by the title reaction [Eq.(1)] by use of the aldolase antibody 38C2 or 33F12; the ee values of the unconverted aldols are greater than 95% in most cases. Since the antibodies also catalyze the aldol reaction–that is, the reverse reaction–it is possible to prepare both enantiomers using the same antibody catalysts.

This publication has 0 references indexed in Scilit: