Can Multivalency Be Expressed Kinetically? The Answer Is Yes
- 10 February 2004
- journal article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 126 (8) , 2288-2289
- https://doi.org/10.1021/ja0395285
Abstract
Inspired by the concept of multivalency and in pursuit of ever more intricate artificial molecular machines, we investigated the strict self-assembly of a triply threaded two-component superbundle, starting from a tritopic receptor in which three benzo[24]crown-8 macrorings are fused onto a triphenylene core and a trifurcated trication wherein three bipyridinium units are linked 1,3,5 to a central benzenoid core. The result of the investigation was quite unexpected and surprising. It transpired that the rapid formation of a doubly threaded two-component complex was followed by an extremely slow conversion (a week at 253 K in CD3COCD3 to reach equilibrium) of this kinetically controlled product into a thermodynamically controlled one, namely a triply threaded two-component superbundle. This intriguing observation begs the question: are there instances in nature where multivalency is expressed as a kinetically controlled process, prior to an equilibrium state being reached, and if so, what are the biological implications, if any?Keywords
This publication has 17 references indexed in Scilit:
- Assessment of Cooperativity in Self-AssemblyJournal of the American Chemical Society, 2003
- Controlling Multivalent Interactions in Triply‐Threaded Two‐Component SuperbundlesChemistry – A European Journal, 2003
- Unidirectional rotation in a mechanically interlocked molecular rotorNature, 2003
- Influencing Receptor−Ligand Binding Mechanisms with Multivalent Ligand ArchitectureJournal of the American Chemical Society, 2002
- Functional Materials Based on Self-Assembly of Polymeric SupramoleculesScience, 2002
- Polyvalent Interactions in Biological Systems: Implications for Design and Use of Multivalent Ligands and InhibitorsAngewandte Chemie International Edition in English, 1998
- An Analysis of the Origins of a Cooperative Binding Energy of DimerizationScience, 1998
- The Rise of Plants and Their Effect on Weathering and Atmospheric CO 2Science, 1997
- Thermodynamically Controlled Self‐Assembly of Pseudorotaxanes and Pseudopolyrotaxanes with Different Recognition Motifs Operating Self‐SelectivelyAngewandte Chemie International Edition in English, 1996
- Molecular Self-Assembly and Nanochemistry: a Chemical Strategy for the Synthesis of NanostructuresScience, 1991