The combination of osteomyelitis, Salmonella infection, and sickle-cell anemia was found in three patients aged 33, 8, and 19 years. The infecting organism was identified as Sal. typhi, Sal. st. paul, and Sal. typhimurium, respectively, in the three cases. One patient had been treated with penicillin for two years without success. It is important both to identify the organism and to recognize the nature of the anemia in cases of this sort, for open suppurating lesions that discharge Salmonella are dangerous to attendants and antibiotics are of no avail unless they are adapted to the causative organism.