Structural Diversity of Streptokinase and Activation of Human Plasminogen
- 1 July 2005
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (7) , 4451-3
- https://doi.org/10.1128/iai.73.7.4451-4453.2005
Abstract
The β domain of streptokinase is required for plasminogen activation and contains a region of sequence diversity associated with infection and disease in group A streptococci. We report that mutagenesis of this polymorphic region does not alter plasminogen activation, which suggests an alternative function for this molecular motif in streptococcal disease.Keywords
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