Antileukemic activity of substituted ureidothiazoles, ureidothiadiazoles, and related compounds
- 1 January 1979
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 22 (1) , 28-32
- https://doi.org/10.1021/jm00187a007
Abstract
A number of ureidothiazole and ureidothiadiazole derivatives related to ethyl 4-[[(2-thiazolylamino)carbonyl]-amino]benzoate were prepared and evaluated against the leukemia P-388 tumor system in mice. Preliminary structure-activity relationship study revealed that, among other considerations, active compounds of this series contain either an isothioureido [> N-C(S-).dbd.N-] or an isothiosemicarbazono [> N-C(S-).dbd.N-N.dbd.] structural unit.This publication has 4 references indexed in Scilit:
- Tetramisole analogs as inhibitors of alkaline phosphatase, an enzyme involved in the resistance of neoplastic cells to 6-thiopurinesJournal of Medicinal Chemistry, 1977
- MECHANISM OF ACTION OF 2-AMINO-1,3,4-THIADIAZOLE (NSC 4728)1977
- THE ANTILEUKEMIC ACTION OF 2 THIADIAZOLE DERIVATIVES1960
- EFFECTS OF NICOTINAMIDE AND RELATED COMPOUNDS ON THE ANTILEUKEMIC ACTIVITY OF 2-AMINO-1,3,4-THIADIAZOLE1960