Immunity and inflammation as synergistic mechanisms in the pathogenesis of periodontal disease

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Abstract
The local immune response to challenge antigen injection in sensitized mice was investigated. Challenge injection was administered through the maxillary labial mucosa.The influence of non‐specific inflammation on the challenge response was studied when both were present simultaneously in a local oral tissue site. The results indicate that inflamed tissues react more violently to the presence of horse ferritin‐anti horse ferritin complexes than do non‐inflamed tissues. Although the challenge reaction in non‐inflamed tissues incited an acute inflammatory lesion, this same reaction occurring in inflamed tissue induced an Arthus reaction.