2 cases of erythroplakia of Queyrat of the oral mucosa are presented. In both cases the disease presented as the clinical variety of erythroplakia known as ‘speckled erythroplakia’. In both cases invasive squamous cell carcinoma developed and was fatal in one. The histologic features which support the view that erythroplakia of Queyrat is a different entity from Bowen’s disease are emphasized.