EFFECT OF IRRADIATION ON DEMYELINATION INDUCED BY AVIRULENT SEMLIKI FOREST VIRUS
- 1 January 1977
- journal article
- research article
- Vol. 58 (5) , 459-464
Abstract
A dose of 500 rad total body irradiation before Semliki Forest virus infection was the most effective in producing multiple foci of demyelination in Swiss mice. Animals receiving this dose had the highest virus titer of Semliki Forest virus persisting in the brain and a delayed antibody response. In spite of extensive demyelination no obvious clinical signs such as paralysis were observed.This publication has 8 references indexed in Scilit:
- Maintenance of Latent Herpetic Infection: An Apparent Role for Anti-Viral IgGThe Journal of Immunology, 1974
- Immunosuppression: a means to assess the role of the immune response in acute virus infections.1971
- The Virulence of Original and Derived Strains of Semliki Forest Virus for Mice, Guinea-pigs and RabbitsJournal of General Virology, 1971
- Langat virus encephalitis in mice II. The effect of irradiationEpidemiology and Infection, 1968
- Studies on the nature of the neutralization reaction and the competition for neutralizing antibody between components of the virus system of foot-and-mouth diseaseVirology, 1962
- A Method for the Combined Staining of Cells and Fibers in the Nervous SystemJournal of Neuropathology and Experimental Neurology, 1953