Analytical approximation to the accessible surface area of proteins
- 1 April 1980
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 77 (4) , 1736-1740
- https://doi.org/10.1073/pnas.77.4.1736
Abstract
An analytical substitute is proposed to the geometrical construction that is commonly used in calculating the protein surface area that is accessible to the solvent. A statistical approach leads to an expression of accessible surface areas as a function of distances between pairs of atoms or of residues in the protein structure, assuming only that these atoms or residues are randomly distributed in space but not penetrating each other. This function gives good estimates of the accessible surface area and of the area buried in subunit contacts for a number of proteins. Its evaluation is very fast, and the function can be differentiated, which opens the way to new applications of accessibility measurements in the study of proteins. The presence of domains is easily detected by an automatic procedure based on surface areas only.This publication has 17 references indexed in Scilit:
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