A Case of Pituitary Adrenocorticotropin-Dependent Cushing's Syndrome in the Horse*

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Abstract
In the horse, a syndrome of hirsutism, hyperglycemia, glucosuria, polydipsia, polyuria, polyphagia and progessive debilitation is recognized. The syndrome was associated with adenomas of the pars intermedia of the pituitary and bilateral adrenal hyperplasia or nodular hyperplasia involving primarily the zona fasciculata. The syndrome was ascribed to compression of the hypothalamus by an expanding but functionally inactive pituitary neoplasm. In the present case, with RIA [radioimmunoassay] determination of plasma ACTH concentrations, the syndrome was ascribed to pituitary ACTH-dependent hyperadrenocorticism and likened to human Cushing''s disease.

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