A NEW ZINC-62 COPPER-62 GENERATOR AS A COPPER-62 SOURCE FOR PET RADIOPHARMACEUTICALS

  • 1 November 1989
    • journal article
    • research article
    • Vol. 30  (11) , 1838-1842
Abstract
A new 62Zn/62Cu generator system was designed to provide a readily available 62Cu source for positron emission tomographic radiopharmaceuticals, based on the differences of complex formation between Zn and Cu. Noncarrier added 62Cu was selectively eluted as a glycine complex from 62Zn-adsorbed cation-exchange resin (CG-120, Amberlite), when a glycine solution (200 mM) was used as the eluant. The elution efficiency and radionuclidic purity of 62Cu were 70% and > 99.9%, respectively. Copper in glycine showed solution showed rapid complex formation with dithiosemicarbazone, which is one of the established Cu-binding agents for bifunctional chelating radiopharmaceutical.