A gene-driven approach to the identification of ENU mutants in the mouse
- 19 February 2002
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 30 (3) , 255-256
- https://doi.org/10.1038/ng847
Abstract
The construction of parallel archives of DNA and sperm from mice mutagenized with ethylnitrosurea (ENU) represents a potentially powerful and rapid approach for identifying point mutations in any gene in the mouse genome. We provide support for this approach and report the identification of mutations in the gene (Gjb2) encoding connexin 26, using archives established from the UK ENU mutagenesis program.Keywords
This publication has 14 references indexed in Scilit:
- Functional Annotation of Mouse Genome SequencesScience, 2001
- A systematic, genome-wide, phenotype-driven mutagenesis programme for gene function studies in the mouseNature Genetics, 2000
- Genome-wide, large-scale production of mutant mice by ENU mutagenesisNature Genetics, 2000
- Mouse mutants from chemically mutagenized embryonic stem cellsNature Genetics, 2000
- Genotype-based screen for ENU-induced mutations in mouse embryonic stem cellsNature Genetics, 2000
- Connexin 26 gene linked to a dominant deafnessNature, 1998
- Connexin-26 mutations in sporadic and inherited sensorineural deafnessThe Lancet, 1998
- Identification of mutations in the connexin 26 gene that cause autosomal recessive nonsyndromic hearing lossHuman Mutation, 1998
- Prelingual Deafness: High Prevalence of a 30delG Mutation in the Connexin 26 GeneHuman Molecular Genetics, 1997
- Connexin 26 mutations in hereditary non-syndromic sensorineural deafnessNature, 1997