Renal Colic Associated with Chlorothiazide and Hydrochlorothiazide Therapy

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Abstract
WITHIN the past few years two new drugs, chlorothiazide and hydrochlorothiazide, have been found to be highly successful in the treatment of hypertension and edema of varying causes.1 2 3 4 5 6 7 8 Although these agents are similar chemically, the latter has no double bond in the heterocyclic ring and is the 3,4-dihydro-derivative of chlorothiazide, in which the 3,-4 double bond is saturated by two hydrogen atoms. Pharmacologically, they act in the same manner, in that they inhibit the reabsorption of sodium by the renal tubules and cause a considerable excretion of bicarbonate and potassium.3 , 5 , 8 Several toxic manifestations have been noted as a result of . . .