Successful Allogeneic Bone Marrow Transplantation for Agnogenic Myeloid Metaplasia in a 3-Year-Old Boy

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Abstract
Purpose: Agnogenic myeloid metaplasia (AMM) is a myelo-proliferative disorder characterized by marrow fibrosis. ex-tramedullary hematopoiesis. splenomegaly, and leukoeryth.ro-blastosis with abnormalities ol'red blood cell morphology. This is rarely encountered in children. No conventional curative therapy is known; however, allogeneic bone marrow transplantation (BMT) may eradicate the underlying stem cell abnormality with subsequent normal hematopoiesis. Results: We report a 3-year-old Arab boy who had AMM and who had normal marrow hematopoiesis and markedly reduced fibrosis after high-dose chemotherapy and matched sibling BMT. Conclusions: Allogeneic BMT offers a potential cure for patients with agnogenic myeloid metaplasia. A preparatory regimen containing busulfun and cyelophosphamide appears promising for patients with the disease.