Liver-Spleen Imaging in Patients with Subacute Hepatic Necrosis and Chronic Hepatitis

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Abstract
Tc-99m-sulfur colloid RES images and percutaneous liver biopsies are correlated in 54 patients who presented with signs and symptoms of subacute hepatic necrosis or chronic active hepatitis. The scored Tc-99m-sulfur colloid scan is compared to the histological severity of disease. Serial scans and biopsies are compared. In patients with significant hepatocellular disease, the liver-spleen scan did not correlate well with the histological severity of disease. Changes in the spleen-to-liver ratio are more common than those in the liver or increased bone marrow activity, and appear earlier. In serial studies, changes in the Tc-99m-sulfur colloid scans correlate weakly with changes in histology.

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