Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin).
- 1 September 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 56 (3) , 1010-1017
- https://doi.org/10.1073/pnas.56.3.1010
Abstract
A new in vitro assay for testing lymphocyto-poietic activity of thymic extracts is reported. Utilizing this assay, the preparation and partial purification of a calf thymic lymphocyto-poietic factor, for which the name thymosin is suggested, are described. The properties of the most purified fraction suggest that lymphocyto-poietic activity is associated with a relatively heat-stable carbohydrate-containing protein with a particle size less than 10,000. This product also stimulates lymphocytopoiesis when assayed in vivo. The purified product does not appear to be identical with any of the previously described preparations with lymphocytopoietic activity.This publication has 15 references indexed in Scilit:
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