Serum Agglutinin Levels to Sheep Red Blood Cells in Mice Infected With Rauscher Virus.

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Abstract
Summary Primary agglutinin liters were depressed in mice immunized with sheep red blood cells 8 days or more following inoculation of l0-1 or 10-2 dilutions of Rauscher leukemogenic virus. The extent of depression was proportional to virus dose and could frequently be detected before the appearance of hematological evidence of leukemic development. Immunization 7 days before, at the time of, or 4 days after, viral inoculation did not result in depression of primary titers. In all these instances a lag was noted in antibody response 4 days after the secondary stimulus; however, by 7 or 8 days increases in antibody titers over primary levels were similar in both virus and control groups. Even in mice markedly leukemic at the time of secondary challenge no depression of the secondary response was observed. A possible mechanism concerning the influence of viral leukemogenesis on the immune response is discussed.

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