SUPPRESSION OF RAT CAROTID LESION DEVELOPMENT BY THE CALCIUM-CHANNEL BLOCKER PN-200-110
- 1 July 1986
- journal article
- research article
- Vol. 124 (1) , 88-93
Abstract
Balloon catheter damage of the rat carotid artery endothelium results in an extensive and reproducible neointimal lesion composed of smooth muscle cells and connective matrix. The authors have examined two calcium channel blockers, PN 200-110 and PY 108-068, for their ability to inhibit neointimal lesion development in the rat carotid model. When given subcutaneously (1.0 mg/kg day) both compounds produced rapidly acting and long-lasting hypotension, reducing blood pressure 25-29%. At this dose given daily, PN 200-110 reduced lesion cross-sectional area by 44%, compared with only 25% seen by PY 108-068, which suggests that the antiatherosclerotic effect may not be related to lowering of blood pressure. Furthermore, PN 200-110 did not reduce the extent of platelet deposition (compared with controls) occurring at the denuded vessel surface 1 hour or 24 hours after balloon catheterization, which indicates that the inhibition of lesion development may not reflect an antiplatelet mechanism. The observed inhibition by PN 200-110 may relate to mitogen responses of the smooth muscle cell in the vessel wall (migration and proliferation) involved in lesion progression after endothelial damage.This publication has 24 references indexed in Scilit:
- A low-viscosity epoxy resin embedding medium for electron microscopyPublished by Elsevier ,2004
- Antiatherosclerotic effects of nicardipine and nifedipine in cholesterol-fed rabbits.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1985
- Calcium channel blockers in hypoxic pulmonary hypertensionThe American Journal of Medicine, 1985
- Modification of experimental atherosclerosis by calcium-channel blockersThe American Journal of Cardiology, 1985
- Does nifedipine suppress atherogenesis in WHHL rabbits?Atherosclerosis, 1984
- Mechanism of protection from atherosclerosis by verapamil in the cholesterol-fed rabbitThe American Journal of Cardiology, 1984
- Low density lipoprotein-lowering and high density lipoprotein-elevating effects of nicardipine in ratsBiochemical Pharmacology, 1984
- No effect of nifedipine on atherogenesis in cholesterol-fed rabbits.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., 1984
- Ineffectiveness of Ca2+-antagonists nicardipine and diltiazem on experimental atherosclerosis in cholesterol-fed rabbitsAtherosclerosis, 1984
- Atherosclerosis: Prevention by Agents Not Affecting Abnormal Levels of Blood LipidsScience, 1981