STUDIES ON CHEMOTHERAPY OF PARASITIC HELMINTHS .3. EFFECTS OF TUBEROSTEMONINE FROM STEMONA-JAPONICA ON THE MOTILITY OF PARASITIC HELMINTHS AND ISOLATED HOST TISSUES

Publisher Website
Google Scholar
Abstract
Effects of tuberostemonine (TS), an alkaloid from S. japonica, on the motility of parasitic helminths and isolated frog rectus and mouse ileum were studied. TS (6.7 .times. 10-6-2 .times. 10-5 M) paralyzed the motility of angiostrongylus cantonensis. TS (6.7 .times. 10-5 M) showed contractive effects on the motility of Dipylidium caninum and Fasciola hepatica. Treatment with TS (6.7 .times. 10-5-4.8 .times. 10-4 M) had little effect on the motility of Schistosoma japonicum. TS (6.7 .times. 10-5 M) paralyzed the motility of the mouse isolated ileum pareparation. TS (6.7 .times. 10-7-6.7 .times. 10-6 M) stimulated the twitch response induced by guanidine (2.5 .times. 10-3 M) in the frog isolated rectus preparation. Eserine and TS acted antagonistically on all preparations with the exception of S. japonicum. TS and strychnine were antagonisttic in isolated host tissues; these compounds acted similarly on parasitic helminths. Some of the experimental effects of the crude extracts of Stemona, such as the anthelmintic effects, are caused through the action of TS on parasitic helminths and host tissues.

This publication has 0 references indexed in Scilit: