Antihypertensive and Hemodynamic Effects of Ticrynafen Compared with Hydrochlorothiazide
- 1 January 1979
- journal article
- clinical trial
- Published by S. Karger AG in Nephron
- Vol. 23 (1) , 51-56
- https://doi.org/10.1159/000181669
Abstract
A double-blind study was performed in 33 ambulatory men, 27 black and 6 white, with mild to moderate essential hypertension to evaluate antihypertensive effects of ticrynafen (Ty) versus hydrochlorothiazide (HTZ), each administered for 24 weeks. Heart rate did not change supine and increased slightly on standing. However, systolic, diastolic and mean blood pressure all decreased significantly with either treatment, whether the patients were supine or standing. Standing diastolic blood pressure dropped from 104.50 ± 5.6 to 92.4 ± 8.9 mm Hg (pKeywords
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