THE MODERATION OF ELASTASE-INDUCED EMPHYSEMA IN THE HAMSTER BY INTRA-TRACHEAL PRETREATMENT OR POST-TREATMENT WITH SUCCINYL ALANYL ALANYL PROLYL VALINE CHLOROMETHYL KETONE

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Abstract
The capacity of the synthetic elastase inhibitor, succinyl alanyl alanyl prolyl valine chloromethyl ketone (CMK), to moderate elastase-induced emphysema in hamsters was examined using morphometric and physiologic measurements. When 0.5 mg CMK in saline was injected intratracheally 1 h before the intratracheal injection of 0.1 mg porcine pancreatic elastase, the hamsters did not develop emphysema. When CMK was injected intratracheally 1 h after elastase, the severity of emphysema was reduced by .apprx. 50% compared to control animals receiving saline 1 h after elastase. CMK was ineffective when administered intratracheally 4 h after elastase.