CANRENOATE - SPIRONOLACTONE METABOLITE - ACUTE CARDIAC EFFECTS IN DIGITALIZED PATIENTS

  • 1 January 1979
    • journal article
    • research article
    • Vol. 10  (2) , 143-149
Abstract
Canrenoate (Soldactone), aspironolactone metabolite for i.v. use, has recently been suggested as a specific antidote in patients suffering from digitalis intoxication. The influence of canrenoate on inotropy in 12 digitalized patients was investigated by measurement of systolic time intervals. Canrenoate improved the left ventricular contractility, since both preejection period (PEP) and the ratio between PEP and left ventricular ejection time (PEP/LVET) decreased significantly. The maximal changes in PEP/LVET occurred 15 min after canrenoate injection. In 10 patients with dogoxin-controlled atrial fibrillation, canrenoate had no effect on ventricular rate, whereas atropine increased the ventricular rate significantly.