Effect of Medullo-adrenalectomy upon Urinary Excretion of Adrenaline and Noradrenaline in Cats

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Abstract
Urine of cats was collected before and after medullo-adrenalectomy and was analyzed fluorimet-rically for epinephrine and nor epinephrine. Bilateral medullo-adrenalectomy was performed in 2 stages under sodium pentobarbital anesthesia. Urinary excretions of epinephrine and norepenephrine were not changed by unilateral medullo-adrenalectomy. After bilateral medullo-adrenalectomy, the excretion of epinephrine was reduced markedly, whereas that of norepenephrine was not changed. The results indicate that epinephrine excreted in urine is derived mainly from the adrenal medulla and, in part, from the other sources, while norepenephrine in urine comes mainly from extra-adrenal origins, presumably the endings of adrenergic nerve fibers.