In Vitro Sensitivity of Human Cells to Lymphocyte Proliferation Inhibitory Factor2
- 1 September 1972
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 49 (3) , 631-638
- https://doi.org/10.1093/jnci/49.3.631
Abstract
Twelve human cell types of malignant and nonmalignant origin examined in vitro possessed a wide range of sensitivity to human lymphocyte-derived proliferation inhibitory factor (PIF). Nontoxic inhibition of “target cell” replication was most marked in primary monolayer cultures of human amnion, least marked in primary cultures of human kidney, and absent in cultures of simian virus 40-transformed WI-38. No apparent correlation existed between human target cell sensitivity to PIF and the parameters of cell origin, in vitro growth characteristics, in vitro morphology, or state of ploidy.Keywords
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