Synthesis of 5-Substituted Pyrimidines through ortho-Directed Lithiation Reactions
- 1 January 1987
- journal article
- research article
- Published by CLOCKSS Archive in HETEROCYCLES
- Vol. 26 (3) , 585-589
- https://doi.org/10.3987/r-1987-03-0585
Abstract
Treatment of 2- and/or 4-substituted pyrimidine with LiTMP in ether at 0.degree. C, followed by quenching with various electrophiles afforded the corresponding 5-substituted pyrimidines.Keywords
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