Acetaminophen, Alcohol, and Cytochrome P-450

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Abstract
Acetaminophen (N-acetyl-p-aminophenol) was first synthesized in the late 19th century (along with acetanilide and phenacetin) and, after recognition of its mild analgesic-antipyretic properties, has been variably used in humans ever since. Although its use was not as great as that of its analog, phenacetin, over the first half of the 20th century, this situation reversed itself in the 1960s and 1970s as phenacetin was increasingly incriminated as a cause of chronic renal injury (1). Acetaminophen is now clearly the major alternative to aspirin in the United States and most other Western countries for the relief of minor aches and pains

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