α,β-Unsaturated Carboxylic Acid Derivatives. XII. A Convenient Synthesis of Oxazole-4-carboxylic and 3,3-Dibromo-2,2-diamino Acids
- 1 July 1977
- journal article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 50 (7) , 1788-1792
- https://doi.org/10.1246/bcsj.50.1788
Abstract
Treatment of t-butyl 2-acetylamino-3-bromo-2-alkenoate with triethylamine gave t-butyl 5-alkyl-2-methyloxazole-4-carboxylate by dehydrobromination, but no reaction occurred with primary amines. While treatment of t-butyl 2-acetylimino-3,3-dibromoalkanoate with hydroxylamine or several aliphatic and aromatic primary amines gave addition products, t-butyl 2-acetylamino-3,3-dibromo-2-(hydroxyamino)- and 2-(substituted amino)alkanoate, respectively, in fairly good yields.This publication has 4 references indexed in Scilit:
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